H2N2V1, Main, Exploration, bibRecord, 000983

Local innate immune responses and influenza virus transmission and virulence in ferrets.

Identifieur interne : 000983 ( Main/Exploration ); précédent : 000982; suivant : 000984

Local innate immune responses and influenza virus transmission and virulence in ferrets.

Auteurs : Taronna R. Maines [Canada] ; Jessica A. Belser [Canada] ; Kortney M. Gustin [Canada] ; Neal Van Hoeven [Canada] ; Hui Zeng [Canada] ; Nicholas Svitek [Canada] ; Veronika Von Messling [Canada] ; Jacqueline M. Katz [Canada] ; Terrence M. Tumpey [Canada]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 2012-02-01.

RBID : Hal:pasteur-00817608

Abstract

Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the innate immune response of ferrets after infection with this virus. The goal of this study was to investigate the contribution of localized host responses to influenza virus pathogenicity and transmissibility in this model by measuring the level of messenger RNA expression of 12 cytokines and chemokines in the upper and lower respiratory tracts of ferrets infected with H5N1, H1N1, or H3N2 influenza viruses that exhibit diverse virulence and transmissibility in ferrets. We found a strong temporal correlation between inflammatory mediators and the kinetics and frequency of transmission, clinical signs associated with transmission, peak virus shedding, and virulence. Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00817608

DOI: 10.1093/infdis/jir768

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000331
to stream Hal, to step Curation: 000331
to stream Hal, to step Checkpoint: 000193
to stream Main, to step Merge: 000984
to stream Main, to step Curation: 000983

Le document en format XML

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</tutelle>
</tutelles>
</hal:affiliation>
<country>Canada</country>
</affiliation>
</author>
<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-221004" status="INCOMING">          <orgName>Influenza Division, National Center for Immunization and Respiratory Disease</orgName>
          <desc>            <address>              <addrLine>Atlanta, Georgia</addrLine>
              <country key="CA"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-312442" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-312442" type="direct"><org type="regroupinstitution" xml:id="struct-312442" status="VALID">          <orgName>Centers for Disease Control and Prevention</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
            <ref type="url">https://www.cdc.gov/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Canada</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1093/infdis/jir768</idno>
<series><title level="j">Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date type="datePub">2012-02-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the innate immune response of ferrets after infection with this virus. The goal of this study was to investigate the contribution of localized host responses to influenza virus pathogenicity and transmissibility in this model by measuring the level of messenger RNA expression of 12 cytokines and chemokines in the upper and lower respiratory tracts of ferrets infected with H5N1, H1N1, or H3N2 influenza viruses that exhibit diverse virulence and transmissibility in ferrets. We found a strong temporal correlation between inflammatory mediators and the kinetics and frequency of transmission, clinical signs associated with transmission, peak virus shedding, and virulence. Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R" last="Maines">Taronna R. Maines</name>
</noRegion>
<name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A" last="Belser">Jessica A. Belser</name>
<name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M" last="Gustin">Kortney M. Gustin</name>
<name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M" last="Katz">Jacqueline M. Katz</name>
<name sortKey="Svitek, Nicholas" sort="Svitek, Nicholas" uniqKey="Svitek N" first="Nicholas" last="Svitek">Nicholas Svitek</name>
<name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name>
<name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name>
<name sortKey="Von Messling, Veronika" sort="Von Messling, Veronika" uniqKey="Von Messling V" first="Veronika" last="Von Messling">Veronika Von Messling</name>
<name sortKey="Zeng, Hui" sort="Zeng, Hui" uniqKey="Zeng H" first="Hui" last="Zeng">Hui Zeng</name>
</country>
</tree>
</affiliations>
</record>

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Local innate immune responses and influenza virus transmission and virulence in ferrets.

Local innate immune responses and influenza virus transmission and virulence in ferrets.

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